Paediatric nephrologist often needs to consider
multiple factors to drug dosing for children with impaired
renal function. They usually convert adult dosing
guidelines into paediatric doses and adjust them to
the patient’s renal function, a procedure that is timeconsuming
and error-prone. It is said that drug
absorption, distribution, metabolism and excretion is
different in children than adults.1 In newborn, the
elimination of drugs is low because of insufficient drug
metabolizing capacity of the liver and immaturity of
kidney function. These alterations of drug metabolism
are correlated to age-adjusted hormonal changes.2 In
this review, dosing tables of some important and
commonly used antimicrobials are provided for easy
and quick reference in order to facilitate prescription
for children with impaired renal function.