GULSHAN NIGAR CHAUDHURY1, MOHAMMED HANIF2, MAHENAZ AFROZ3, DILRUBA BEGUM4
Abstract
Background: Biochemical alteration is a common phenomenon in all kidney disease
including nephrotic syndrome (NS).
Objective: To evaluate the magnesium (Mg) level in patients with nephrotic syndrome
and its relation to calcium.
Methods: In this observational cross sectional study,we measured serum magnesium
and serum calcium levels in children with nephrotic syndrome.It was conducted in the
Department of Pediatrics, Dhaka Shishu(children) Hospital, Dhaka, from January
2015 to June 2015. A total of fifty four diagnosed cases of nephrotic syndrome were
divided into initial episode, first relapse,infrequent relapse and frequent relapse. Mean
level of serum magnesium and calcium of all four groups were then compared.
Results :The mean level of serum magnesium during initial episode was 2.28±0.36mg/
dl and it was 2.04±0.29,2.06±0.29 and 1.76±0.32mg/dl during first relapse, infrequent
relapse and frequent relapse respectively. The mean serum magnesium level in
different patterns of nephrotic syndrome was found to be statistically significant.
Hypomagnesemia was mostly found in frequent relapse nephrotic syndrome patients.
The mean level of serum calcium during initial episode was 2.01±0.16 and it was
1.98±0.17,2.06±0.13 and 2.05±0.15 during first relapse, infrequent relapse and frequent
relapse respectively. The mean serum calcium level in different patterns of nephrotic
syndrome was found to be statistically insignificant. There was no significant corelation
between calcium level with magnesium level (r = -0.08, p = 0.28).
Conclusion: Hypomagnesemia is commonly found in frequent relapse nephrotic
syndrome. There was no significant correlation between calcium with magnesium
level.
Key words: Nephrotic syndrome, magnesium, calcium.