Congenital Cytomegalovirus Infection As Lissencephaly – A Case Report

Introduction: Human cytomegalovirus is 1 of 8 human herpes viruses. Congenital cytomegalovirus infection is a leading cause of intrauterine infection and brain damage in children.1–3 Primary infection occurs in as many as 2.2% of pregnant women4 and serologic or culture evidence of intrauterine CMV infection has been reported in 0.2–2.2% of all live-born neonates.5 Among infected neonates, 90–95% are asymptomatic at birth, but almost 30% develop late complications in the 1st year of life. 5 Fetal infection results from transmission of the virus across the pla-centa and is particularly common in women who experience primary infection during pregnancy. 6 According to two large systematic literature reviews performed in 2007 examining the epidemiology and outcome of congenital CMV infection, the prevalence of infection at birth was 0.6%–0.7% in industrialized countries and among those with congenital infection, 11%–13% of patients were symptomatic. 7,8 Neurologic findings of congenital CMV infection include intracranial calcification, migrational abnormalities, cerebral and cerebellar

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