Introduction: Neurofibromatosis is a neurocutaneous syndrome, mostly familial in origin and believed to arise from a defect in differentiation of the primitive ectoderm. There are two distinct forms of neurofibromatosis – type-1 and type- 21. Neurofibromatosis type-1 (NF-1), previously known … Continue reading →

Introduction: The Myelodysplastic Syndrome (MDS) were historically characterized by a cellular marrow with peripheral cytopenias. They were described as smouldering leukaemia or pre-leukaemia. These disorders were predominantly of late adult life and have since been well classified in the extensive … Continue reading →

Abstract Magneting resonance imaging in subacute sclerosing panencephalitis (SSPE) usually demonstrates changes in periventicular and subcortical white matter. Basal ganglia, Cerebellum, Spinal cord are less commonly involved. In this article, we report two cases of SSPE associated with basal ganglia … Continue reading →

Introduction: Haemophilia is a coagulation disorder caused by deficiency of factor VIII (FVIII) and factor IX (FIX), prevalence of which is about 1 in 10,000 male births1. It is an “X” linked hereditary disorder. This results in males being affected … Continue reading →

Summary: Background: Acute bacterial meningitis (ABM) is one of the common causes of morbidity and mortality in children. Easy and early diagnostic tool is required for rapid detection of acute bacterial meningitis to reduce mortality and morbidity. Objectives: The study … Continue reading →

Abstract Introduction: Nausea and vomiting are the most important side effects of cytotoxic chemotherapy and it is reported by the patients who receive chemotherapy for malignancies. Ondansetron and granisetron(5 HT3 receptor antagonists) are effective compounds with relatively less toxicity to … Continue reading →

Abstract Background : Gastroschisis is a congenital abdominal wall defect with high mortality in developing countries. In developed countries their survival rate is more than ninety percent. This is due to appropriate information about the disease and adequate management plan. … Continue reading →

Abstract Background: Seizure is a common neurological disorder in neonatal age group. Primary metabolic derangement is one of the common reason behind this convulsion during this period. Among metabolic abnormalities, hypocalcaemia is most common followed by hypoglycemia and hypomagnesaemia. Objectives: … Continue reading →

Introduction: Primary immunodeficiency disorders (PIDs) are rare inherited conditions that predispose individuals to infections that are recurrent due to unusual organisms. PIDs are also often associated with autoimmune, haematological and malignant disorders1. Primary immunodeficiency have many clinical similarities with, but … Continue reading →

Introduction Preterm birth, defined as childbirth occurring at less than 37 completed weeks or 259 days of gestation, is a major determinant of neonatal mortality and morbidity and has long-term adverse consequences for health1–3. Children who are born prematurely have … Continue reading →